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KMID : 0388220080150010001
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Journal of the Korean Rheumatism Association
2008 Volume.15 No. 1 p.1 ~ p.10
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Intracellular Signal Transduction Pathways and Transcription Factors for Osteogenesis
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Im Gun-Il
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Abstract
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Osteoblastic differentiations of mesenchymal stem cells are controlled by a number of intracellular signal transduction systems and transcription factors. These systems and factors interacts with and cross-talks to one another to complete the process of bone formation. Discovery of these systems has been enabled by gene-targeting techniques. In this brief review, the signal transduction pathways and transcription factors of importance to osteoblastic differentiation are introduced.
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KEYWORD
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Signal transduction pathway, Transcription factor, Osteogenesis, Bone
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